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Scientific Programme eCM XI 2010:
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| 08:30 – 08:45 | Welcome Dr. Sibylle Grad |
| 08:45– 09:00 | AO Research Institute Davos Prof. RG Richards |
Development
Session 1 Chair: Charlie
W. Archer
| 09:00 – 09:30 | Alison
Cole (Biogem s.c.a.r.l., Ariano Irpino, I) Diversity in development and evolution of cartilages |
| 09:30 – 10:00 | Christine Hartmann
(IMP Research, Vienna, A) The various functions of Wnt-signaling in chondrogenesis |
| 10:00 – 10:15 | Chondroitin sulphate sulfation motifs in intervertebral disc
development Jim Ralphs, Bruce Caterson, Clare Hughes and Anthony Hayes |
| 10:15 – 10:30 | Acceleration of post-natal articular cartilage maturation Ilyas M Khan, Sam L Evans, Nick Avery & Charles W Archer |
10:30 – 11:00 Coffee Break
Maintenance
Session 2 Chair: Bruce Caterson
| 11:00 – 1:30 | Tonia Vincent
(Faculty of Medicine, London, GB) The role of biomechanical factors in OA development |
| 11:30 – 11:45 | Eicosapenaenoic acid (EPA) and docasahexaenoic acid (DHA)
reduce IL-1? mediated cartilage degradation AK.Wann, J.Mistry, A.Michael-Titus, MM.Knight |
| 11:45 – 12:00 | Cell interactions of osteoarthritic subchondral bone osteoblasts
and articular chondrocytes aggravate MMP-2 and MMP-9 production through the mediation of ERK1/2 and JNK phosphorylation I. Prasadam, R. Crawford, Y. Xiao |
| 12:00 – 12:30 | Mary Goldring (HSS,
New York, USA) Roles of inflammatory and anabolic cytokines in cartilage metabolism |
Free afternoon
Degeneration
Session 3 Chair: Peter Roughley
| 17:00 – 17:30 | Francesco
Dell’Accio (Queen Mary University, London, GB) Molecular mechanisms of cartilage regeneration |
| 17:30 – 17:45 | Angiogenic factors, mechanical loads and oxygen supply: possible
interactions in the regulation of degeneration associated disc
angiogenesis? C. Neidlinger-Wilke, A. Mietsch, U.M. Mauer, H.J. Wilke, A. Ignatius |
| 17:45 – 18:00 | Identification of Human Nucleus Pulposus (NP) and Articular
Cartilage (AC) Marker Genes and their Expression in the Degenerate NP. BM. Minogue, SM. Richardson, JA Hoyland. |
| 18:00 – 18:15 | Burst fracture of the vertebral endplates but not equienergetic
impact load promotes in vitro disc degeneration S. Dudli, D. Haschtmann, S.J. Ferguson |
18:15 – 20:00 Poster session (Drinks & Snacks)
Tuesday, June 29th
Scaffolds
Session 4 Chair: David Eglin
| 08:30 – 09:00 | Abhay Pandit
Hierarchical functionalization of scaffold – macro to nano |
| 09:00 – 09:30 | Molly Stevens Modulation of cell behaviour through nanoscale architecture |
| 09:30 – 09:45 | Injectable thermoreversible hyaluronan-based hydrogels for
interveterbral disc repair. M.Peroglio, D.Mortisen, M.Alini, D.Eglin |
| 09:45 – 10:00 | Tailoring self-assembled octapeptide scaffolds for in-vitro
cartilage repair A Mujeeb, J Gough & A Saiani |
| 10:00 – 10:15 | Substrate elasticity modulates TGF beta stimulated re-differentiation
of expanded human articular chondrocytes D. Vonwil, A. Barbero, A. Trüssel, O. Haupt, I. Martin |
10:15 – 11:00 Coffee Break
Mechano-Regulation
Session 5 Chair: Martin Stoddart
| 11:00 – 11:30 | James Iatridis
(University of Vermont, Burlington, USA) Effects of Shearing on Intervertebral Disc Mechanics and Biology |
| 11:30 – 12:00 | Robert Mauck (University
of Pennsylvania, Philadelphia, USA) Effect of mechanical stress on chondrogenesis |
| 12:00 – 12:15 | Primary cilia are essential for chondrocyte mechanotransduction AK.Wann, SR.McGlashan, CJ.Haycraft, CA.Poole, MM.Knight |
| 12:15 – 12:30 | Development Of An Ex Vivo Disc Model System To Test Novel
Therapies: Comparison of Loaded Isolated Discs Vs Whole Motion Segments. E.A.Mitchell, A.M.White, S.M.Richardson, J.A.Hoyland |
Free afternoon
18:00 Conference Dinner
Wednesday, June 30th
Clinical
Session 6 Chair: Geoff Richards
| 08:30 – 09:00 | Wayne Mcllwraith
(Colorado State University, Fort Collins, USA) Animal models for cartilage regeneration |
| 09:00 – 09:20 | Bone substitution in subchondral bone and its effect on hyaline
cartilage - an experimental study in sheep B. von Rechenburg |
| 09:20 – 09:35 | Non-destructive evaluation of human mesenchymal progenitor
cell transcriptional activity within osteochondral defects R.M. Porter, F.J. Liu, E. Ferreira, Z. Shen, and C.H. Evans |
| 09:35 – 09:50 | Cellular synergy for one step cartilage repair J. Hendriks, R. Schotel, M. van den Doel, J. Riesle |
| 09:50 – 10:20 | James Richardson (Oswestry
Orthopaedic Hospital, Oswestry, GB) Runaway Remodelling and its implications for treatment of osteoarthritis in the clinic |
| 10:20 – 10:50 | Constantin Schizas
(University Hospital, Lausanne, CH) Disc degeneration: current surgical techniques |
10:50 – 11:15 Coffee Break
Repair
Session 7 Chair: Chris Evans
| 11:15 – 11:45 | Anthony
Hollander (University of Bristol, Bristol, GB) Stem cells and cartilage repair: turning science into medicine |
| 11:45 – 12:15 | Judith Hoyland (University
of Manchester, Manchester, GB) Challenges for Cell Based Regeneration of the Degenerate Intervertebral Disc |
| 12:15 – 12:30 | Downregulation of Superfluous Genes on Commitment to Chondrogenic
Differentiation of Mesenchymal Stem Cells is associated with
DNA Hypermethylation C.ÓFlatharta, E.Mooney, M.Berdasco, G.Shaw, M.Esteller, FB.Barry, JM.Murphy |
| 12:30 – 12:45 | Direct, rAAV-mediated Overexpression of Human IGF-I Enhances
Articular Cartilage Repair in Vivo M. Cucchiarini, MD. Menger H. Madry |
| 12:45 – 13:00 | Best student oral and poster prizes |
| 13:00 – 13.15 | Conference summary (Prof. C. W. Archer & Prof. M. Alini) |
Conference End
We advise all presenters to look at the TIPS
FOR TALKS (548 kB) presentation and read these guidelines
(39kB) before starting to prepare their talks. Science is in the
detail. It is the lifeblood of science to discuss.
All invited talks
are 20 minutes (20-30 slides)
to allow 10 minutes discussion per talk.
All submitted talks are 10 minutes (10-15 slides) to allow
5 minutes discussion per talk.
Chairpersons will cut people off who try to use this time for their
talks!
Please bring a copy of your talk on CD or USB stick to give to Presentation
Support, Sunday evening at Registration.Paper Submission
We invite all keynote speakers to submit a paper (either original
research report, original review*or original tutorial*) to the European
Cells & Materials (eCM) online 'Open & Free Access' journal.*NOTE:
We define a REVIEW PAPER as a paper which includes an extended literature
review and complete bibliography (including authors' own work),
and can also emphasise authors' new unpublished findings and in
an extended discussion puts the topic in proper perspective. A review
can also be based on a complete bibliography of an author's own
work over several years in relation to others. A TUTORIAL PAPER
contains an organised comprehensive review of all relevant published
material as for a teaching lecture.
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