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eCM XII: Implant Infection
(Main focus orthopedic and trauma related infections)

22nd - 24th June, 2011, Congress Center, Davos, Switzerland

(Programme is subject to last minute changes)

Wednesday, June 22nd

08:30 – 08:40 R Geoff Richards AO Research Institute Davos
08:40 – 08:50 Jaime Quintero President-elect AO Foundation
08:50 – 09:00 Sibylle Grad Welcome to Davos
   

 


Musculoskeletal Infection
Session 1 Chair: Geoff Richards

09:00 – 09:30

Charlarampas Zalavras (USA)
Surgical treatment of infection in the presence of fracture fixation implants

09:30 – 09:45

Sequential Release Kinetics of Two (Gentamicin and BMP-2) or Three (Gentamicin, IGF-1 and BMP-2) Substances from one-component Polymeric Coating on Implants        
Britt Wildemann*

09:45 –10:00

Daptomycin – Local Applications in Implant-Associated Infection and Complicated Osteomyelitis
Steffen Rosslenbroich*

10:00 – 10:30 Henk Busscher (NL)
Biomaterials-related infection-the race for the surface and beyond

 

10:30 – 11:00 Coffee Break

Anti-infective strategies I
Session 2 Chairs:Hans Griesser, Henk Busscher

11:00 – 1:30

Christof Berberich (DE)
Antibiotics in orthopedic use – is there a right choice?

11:30 – 11:45

Ag/SiOxCy plasma polymer coating for antimicrobial protection of fracture fixation devices  
V.Alt, P. Khalilpour, M. Wagener, E. Domann, R. Schnettler 

11:45 – 12:00

Controlled release of gentamicin for the prevention of Staphylococcus aureus biofilm formation on fracture fixation implants
R. Steck, D.J. McMillan, C. Lutton, N. Rosenzweig, K.S. Sriprakash, B. Goss,M.A. Schuetz

12:00 – 12:30 Michael Raschke (DE)
Clinical performance of Antibiotic coated Intramedullary nails.

 

Free afternoon


Bacterial Pathogenicity I
Session 3 Chairs:Mark Smeltzer, Fintan Moriarty

17:00 – 17:30 Sebastian Zaat (NL)
Peri-implant tissue as a “safe haven” for biofilm bacteria
17:30 – 17:45

Influence of biomaterials on Staphylococcus epidermidis biofilm formation
L.G.Harris, R.Jeeves, H.Rohde, D.Mack

17:45 – 18:00

Effects of rifampicin-fosfomycin coating for cementless endoprostheses against methicillin-sensitive S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) 
V.Alt, K. Lips, N. Düwelhenke, E. Domann, R. Schnettler

18:00 – 18:30 Magnus Höök (USA)
S. aureus MSCRAMMS in Bone Infections


18:30 – 20:00 Poster session (Drinks & Snacks)

Thursday, June 23rd

Anti-Infective strategies II
Session 4 Chairs: Michael Raschke, Llinos Harris

08:30 – 09:00 Klaus Dieter Kühn (DE)
Novel strategy of anti-infective implant coating in medicine
09:00 – 09:15

Protecting polymer surfaces against bacterial adhesion and biofilm formation
Hans J. Griesser, Krasimir Vasilev, Hardi Ys, Chi Ndi, Stefani S. Griesser, Marek Jasieniak, Htwe Mon, Susan Semple

09:15 – 09:30

Bone cell viability and antibacterial efficacy of porous TiO2-Ag coatings
B.S. Necula, L.E. Fratila Apachitei, J.P.T.M. van Leeuwen, S.A.J. Zaat, I. Apachitei, J. Duszczyk

09:30 – 09:45

Antibacterial HA coatings with defined crystallinity to tune Ag release
S.Lischer, C.R. Bradbury, B.Wampfler, Q.Ren, Ph.Gruner, K.Maniura

09:45 – 10:15

Noam Emanuel (IS)
PolyPid - A novel local delivery system: from the physic-chemical aspects to innovative and superior therapeutic potential.

 

10:15 – 11:00 Coffee Break


Bacterial pathogenicity II
Session 5 Chairs: Mark Shirtliff, Charlarampas Zalavras

11:00 – 11:30 Mark Smeltzer (USA)
Alternative approaches for the diagnosis and treatment of staphylococcal biofilm-associated infection
11:30 – 11:45

Serrulatane EN4, a New Antimicrobial Compound Exerts Potent Acitvity against Adherent Biofilm-Forming Bacteria In Vitro
J. Nowakowska, H. J. Griesser, C. Acikgoz, M. Textor, R. Landmann, N. Khanna  

11:45 – 12:00

Characterization of a three-species biofilm in vitro
M. Astasov-Frauenhoffer, O. Braissant, I. Hauser-Gerspach, A. U. Daniels, R. Weiger, T. Waltimo

12:00 – 12:30

Dietrich Mack (UK)
Mechanisms of Staphylococcus epidermidis biofilm formation in different types of biomaterial-related infections

   


Free afternoon

Tour of AO center / Optional Hike in the vicinity of Davos

Immunological aspects of implant related infection
Session 6 Chairs: Sebastian A.J. Zaat, Dietrich Mack

17:00 – 17:30 Mark Shirtliff (USA)
Novel vaccine strategies and improved diagnostics for musculoskeletal infections
17:30 – 17:45

Development of a Passive Immunization for Methicillin-Resistant Staphylococcus aureus (MRSA) Osteomyelitis
SL. Kates, JJ. Varrone, JL. Daiss, EM. Schwarz

17:45 – 18:00

In Vitro Modelling of Interactions between Bacteria, Osteoblast-like cells and Macrophages in the Pathogenesis of Biomaterial-Associated Infections
R. Kuijer, G. Subbiahdoss, I.C. Saldarriaga Fernández, J.F. da Silva Domingues, H.C. van der Mei, H.J. Busscher

18:00 – 18:30

Jos A.G. van Strijp (NL)
Molecular mechanisms of complement evasion


Free evening



Friday, June 24th

Asia Pacific Orthopaedic Association Session
Session 7 Chairs: Sureshan Sivananthan, John Fairclough

08:30 – 08:40

Sureshan Sivananthan
Introduction

08:40 – 09:10

Said Saghieh (Lebanon)
Treatment of infected non-union of the long bones with calcium sulfate pellets impregnated with antibiotics

09:10 – 09:40 John Fairclough (UK)
The surgical ritual – The myths and the science
09:40 – 09:55 166 Cases of Mycobaterium Marinum Tenosynovitis of the Hand and Wrist: Clinical Features, Management and Results       
Jason P Y Cheung*
09:55 – 10:10

The Role of Occult Infection in the Aetiology of Aseptic Loosening Of Joint Arthroplasty Using Ultrasound Sonication and Conventional Sampling Techniques        
J Kempthorne*

10:10 – 10:20

APOA Session closing

10:20 – 11:00 Coffee Break


Diagnosis and Imaging of infection
Session 8 Chairs: Stephen Kates, J.W. Costerton

11:00 – 11:30  

Alberto Signore (Italy)
Radiolabelled leukocytes, antibodies and FDG for imaging infection associated to prostheses

11:30 – 12:00

Vincent Stadlemann (CH)
Non-invasive biomechanical assessment of implant fixation with in-vivo computed tomography: perspectives for infected implants

12:00 – 12:15

From swab to SEM: Our protocol on TKA infection suspicion
R.Ferrari, C.C.Castelli A.Goglio, A.Grigis, A. Raglio, S.Buoro, G.Virotta, A.Remuzzi, L.Condorelli

12:15 – 12:30

Comparison of Cultures with a New Multiplex PC/Mass Spec. for the Detection of Orthopedic Biofilm Infections.
J.W. Costerton, N. Sotereanos and P.J. DeMeo

   
   

12:30 – 14:30 Lunch

Clinical focus
Session 9 Chairs: Niklaus Renner, Werner Zimmerli

14:30 – 15:00

IM Shapiro (USA)
Molecular Engineering of an Orthopaedic Implant: From Bench to Bedside

15:00 – 15:10

Clinical Presentation and Bacteriological Analysis of Fight Bite Injuries in Tropical North Queensland
A.S. Miller, T. Ayres, P. Musio, J McBride, Wonnacott   Dir

15:10 – 15:20

Detection of periprosthetic joint infections: Blood infection markers in patients undergoing revision arthroplasty
T. Randau, M. Wimmer, D. Kuberra, B. Reichert, B. Stoffel-Wagner, D.-C. Wirtz, S. Gravius

15:20 – 15:30

The use of Antimicrobial Peptides to prevent Implant Infections: Experimental Options and Review of Literature
S Sivananthan

15:30 – 16:00

Werner Zimmerli (CH)
Antimicrobial treatment of implant-associated infections

16:00 – 16:10 RMS Student prize announcements & Conference closing

* Pfizer prize entrant

18:00 Conference Dinner including APOA Pfizer prize giving ceremony

Conference End

We advise all presenters to look at the TIPS FOR TALKS (548 kB) presentation and read these guidelines (39kB) before starting to prepare their talks. Science is in the detail. It is the lifeblood of science to discuss.

All invited talks are 20 minutes (20-30 slides) to allow 10 minutes discussion per talk.
All submitted talks are 10 minutes (10-15 slides) to allow 5 minutes discussion per talk.

Chairpersons will cut people off who try to use this time for their talks!
Please bring a copy of your talk on CD or USB stick to give to Presentation Support, Wednesday morning at Registration.
Paper Submission
We invite all keynote speakers to submit a paper (either original research report, original review*or original tutorial*) to the European Cells & Materials (eCM) online 'Open & Free Access' journal.*NOTE: We define a REVIEW PAPER as a paper which includes an extended literature review and complete bibliography (including authors' own work), and can also emphasise authors' new unpublished findings and in an extended discussion puts the topic in proper perspective. A review can also be based on a complete bibliography of an author's own work over several years in relation to others. A TUTORIAL PAPER contains an organised comprehensive review of all relevant published material as for a teaching lecture.

 


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