eCM Journal
Created by Scientists, for Scientists

ISSN 1473-2262   NLM: 100973416 (link) The leading Journal of musculoskeletal research.
 

Home

Issues / Manuscripts

 

Supplements

Conferences

 About eCM Journal

 

 Scope

 Submission Instructions

 Editors

 Info on eCM

 Sponsors

 Societies

 Contact

 eCM Paper notification

 

  (Info)

 eCM Site search

 
 
 
   
 


2003   Volume No 5 - pages 1-16

Title: Biodegradable synthetic polymers for tissue engineering

Authors: P. A. Gunatillake and R. Adhikari

Address: CSIRO Molecular Science, Bag 10, Clayton South MDC, Vic 3169, Australia

E-mail: Thilak.Gunatillake at csiro.au

Key Words: biodegradable polymers, tissue engineering, degradation, injectable polymers.

Publication date: 20th May 2003

Abstract: This paper reviews biodegradable synthetic polymers focusing on their potential in tissue engineering applications. The major classes of polymers are briefly discussed with regard to synthesis, properties and biodegradability, and known degradation modes and products are indicated based on studies reported in the literature. A vast majority of biodegradable polymers studied belongs to the polyester family, which includes polyglycolides and polylactides. Some disadvantages of these polymers in tissue engineering applications are their poor biocompatibility, release of acidic degradation products, poor processability and loss of mechanical properties very early during degradation. Other degradable polymers such as polyorthoesters, polyanhydrides, polyphosphazenes, and polyurethanes are also discussed and their advantages and disadvantages summarised. With advancements in tissue engineering it has become necessary to develop polymers that meet more demanding requirements. Recent work has focused on developing injectable polymer compositions based on poly (propylene fumarate) and poly (anhydrides) to meet these requirements in orthopaedic tissue engineering. Polyurethanes have received recent attention for development of degradable polymers because of their great potential in tailoring polymer structure to achieve mechanical properties and biodegradability to suit a variety of applications.

Article download: Pages 1-16 (PDF file)

Acrobat Reader:
 

To read this article you will need to install Adobe Acrobat Reader on your computer. Should you experience any difficulty in reading the PDF file we suggest that you save the file to your computer BEFORE opening it from Adobe Acrobat.

Last modified December 18, 2012

Open Access / Author retains copyright

AO Foundation, Davos, Switzerland