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2005 Volume No 9
pages 39-49
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Title: Basic reactions of osteoblasts on structured material
surfaces
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Authors: U. Meyer, A. Büchter, H.P. Wiesmann,
U. Joos and D.B. Jones
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Address: Department of Cranio-Maxillofacial Surgery,
University of Münster, Waldeyerstr. 30, D-48149 Münster.
Germany
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E-mail:
ulrich.meyer at ukmuenster.de
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Key Words: Biomaterials, tissue engineering, osteoblasts,
cell culture
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Publication date: April 26th 2005
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Abstract: In order to assess how bone substitute
materials determine bone formation in vivo it is useful to
understand the mechanisms of the material surface/tissue interaction
on a cellular level. Artificial materials are used in two
applications, as biomaterials alone or as a scaffold for osteoblasts
in a tissue engineering approach. Recently, many efforts have
been undertaken to improve bone regeneration by the use of
structured material surfaces. In vitro studies of bone
cell responses to artificial materials are the basic tool
to determine these interactions. Surface properties of materials
surfaces as well as biophysical constraints at the biomaterial
surface are of major importance since these
features will direct the cell responses. Studies on osteoblastlike
cell reactivity towards materials will have to focus on the
different steps of protein and cell reactions towards
defined surface properties. The introduction of new techniques
allows nowadays the fabrication of materials with ordered
surface structures. This paper gives a review of present knowledge
on the various stages of osteoblast reactions on material
surfaces, focused on basic cell events under in vitro
conditions. Special emphasis is given to
cellular reactions towards ordered nano-sized topographies.
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Article download: Pages
39-49. (PDF file)
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