Abstract: This paper reviews current approaches to the enhancement of bone regeneration at the interface with implant devices, by immobilization of biomolecules to titanium surfaces. In particular, techniques based on surface linking of peptides or extracellular matrix (ECM) proteins are reviewed, trying to describe surface modification approaches and to present results of chemico-physical and biological evaluations, both in vitro and in vivo. Based on existing literature, surface modification by peptides or ECM proteins appears as an effective way to stimulate bone regeneration over that provided by titanium, as suggested by basic studies and in vitro results and confirmed by in vivo findings.

Article download: Pages 1-15 (PDF file)

Acrobat Reader:

To read this article you will need to install Adobe Acrobat Reader on your computer. Should you experience any difficulty in reading the PDF file we suggest that you save the file to your computer BEFORE opening it from Adobe Acrobat.

Last modified by Webmaster, March 27, 2007

AO Foundation