eCM Journal - Not-for-profit Open Access
Created by Scientists, for Scientists

ISSN 1473-2262   NLM: 100973416 (link) The leading Journal of musculoskeletal research.


Issues / Manuscripts




 About eCM Journal



 Submission Instructions


 Info on eCM





2006   Volume No 12 – pages 92-101

Title: The structure and function of cartilage proteoglycans

Author: PJ Roughley

Address: Genetics Unit, Shriners Hospital for Children and Department of Surgery, McGill University, Montreal, Quebec, Canada


E-mail: proughley at


Key Words: Proteoglycan, aggrecan, link protein, hyaluronan, decorin, biglycan, fibromodulin, lumican, cartilage.


Publication date: November 30th 2006

Abstract: Cartilage contains a variety of proteoglycans that are essential for its normal function. These include aggrecan, decorin, biglycan, fibromodulin and lumican. Each proteoglycan serves several functions that are determined by both its core protein and its glycosaminoglycan chains. This review discusses the structure/function relationships of the cartilage proteoglycans, and the manner in which perturbations in proteoglycan structure or abundance can adversely affect tissue function.

Article download: Pages 92-101 (PDF file)

Acrobat Reader:

To read this article you will need to install Adobe Acrobat Reader on your computer. Should you experience any difficulty in reading the PDF file we suggest that you save the file to your computer BEFORE opening it from Adobe Acrobat.

Last modified May 19, 2016

Open Access / Author retains copyright

AO Foundation, Davos, Switzerland