eCM Journal
Created by Scientists, for Scientists

ISSN 1473-2262   NLM: 100973416 (link) The leading Journal of musculoskeletal research.
 

Home

Issues / Manuscripts

 

Supplements

Conferences

 About eCM Journal

 

 Scope

 Submission Instructions

 Editors

 Info on eCM

 Sponsors

 Societies

 Contact

 eCM Paper notification

 

  (Info)

 eCM Site search

 
 
 
   
 


2011   Volume No 21 – pages 407-429

Title: Osteoinductive biomaterials: current knowledge of properties, experimental models and biological mechanisms

Author: AMC Barradas, H Yuan, CA van Blitterswijk, P Habibovic

Address: Department of Tissue Regeneration, University of Twente, MIRA Institute for Biomedical Technology and Technical Medicine, Zuidhorst ZH147, Drienerlolaan 5, 7522 NB Enschede, The Netherlands

E-mail: p.habibovic at tnw.utwente.nl

Key Words: Osteoinduction, biomaterials, ceramics, calcium phosphates, bone regeneration.

Publication date: May 22nd 2011

Abstract: In the past thirty years, a number of biomaterials have shown the ability to induce bone formation when implanted at heterotopic sites, an ability known as osteoinduction. Such biomaterials – osteoinductive biomaterials – hold great potential for the development of new therapies in bone regeneration. Although a variety of well characterised osteoinductive biomaterials have so far been reported in the literature, scientists still lack fundamental understanding of the biological mechanism underlying the phenomenon by which they induce bone formation. This is further complicated by the observations that larger animal models are required for research, since limited, if any, bone induction by biomaterials is observed in smaller animals, including particularly rodents. Besides interspecies variation, variations among individuals of the same species have been observed. Furthermore, comparing different studies and drawing general conclusions is challenging, as these usually differ not only in the physico-chemical and structural properties of the biomaterials, but also in animal model, implantation site and duration of the study. Despite these limitations, the knowledge of material properties relevant for osteoinduction to occur has tremendously increased in the past decades. Here we review the properties of osteoinductive biomaterials, in the light of the model and the conditions under which they were tested. Furthermore, we give an insight into the biological processes governing osteoinduction by biomaterials and our view on the future perspectives in this research field.

Article download: Pages 407-429 (PDF file)

Acrobat Reader:
 

To read this article you will need to install Adobe Acrobat Reader on your computer. Should you experience any difficulty in reading the PDF file we suggest that you save the file to your computer BEFORE opening it from Adobe Acrobat.

Last modified December 18, 2012

Open Access / Author retains copyright

AO Foundation, Davos, Switzerland