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Title: Animal models of maternal nutrition and altered offspring bone structure – Bone development across the lifecourse |
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Author: SA Lanham, C Bertram, C Cooper, ROC Oreffo |
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Address: Bone and Joint Research Group, Human Development and Health, Institute of Developmental Sciences, University of Southampton School of Medicine, Southampton, SO16 6YD, UK |
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E-mail: sal3 at soton.ac.uk |
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Key Words: Animal models, bone, bone development, epidemiology, epigenetics. |
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Publication date: November 24th 2011 |
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Abstract: It is widely accepted that the likelihood of offspring developing heart disease, stroke, or diabetes in later life, is influenced by the their in utero environment and maternal nutrition. There is increasing epidemiological evidence that osteoporosis in the offspring may also be influenced by the mother’s nutrition during pregnancy. This review provides evidence from a range of animal models that supports the epidemiological data; suggesting that lifelong bone development and growth in offspring is determined during gestation. |
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Article download: Pages 321-332 (PDF file) |
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| Last modified November 24, 2011 |