eCM (Eur Cell Mater / e Cells & Materials) Not-for-profit Open Access
Created by Scientists, for Scientists
 ISSN:1473-2262         NLM:100973416 (link)         DOI:10.22203/eCM

2014   Volume No 27s – pages 12-16

Title: A vision on the future of articular cartilage repair

Author: M Cucchiarini, H Madry, F Guilak, DB Saris, MJ Stoddart, M Koon Wong, P Roughley

Address: Genetics Unit, 1529 Cedar Avenue, Shriners Hospital for Children, Montreal, Quebec, H3G 1A6, Canada

E-mail: proughley at shriners.mcgill.ca

Key Words: Articular cartilage repair, microfracture, articular chondrocyte implantation, tissue engineering, neomaterials, cell and gene therapy, articular chondrocytes, progenitor cells.

Publication date: May 6th 2014

Abstract: An AO Foundation (Davos, Switzerland) sponsored workshop "Cell Therapy in Cartilage Repair" from the Symposium "Where Science meets Clinics" (September 5-7, 2013, Davos) gathered leaders from medicine, science, industry, and regulatory organisations to debate the vision of cell therapy in articular cartilage repair and the measures that could be taken to narrow the gap between vision and current practice. Cell-based therapy is already in clinical use to enhance the repair of cartilage lesions, with procedures such as microfracture and articular chondrocyte implantation. However, even though long term follow up is good from a clinical perspective and some of the most rigorous randomised controlled trials in the regenerative medicine/orthopaedics field show beneficial effect, none of these options have proved successful in restoring the original articular cartilage structure and functionality in patients so far. With the remarkable recent advances in experimental research in cell biology (new sources for chondrocytes, stem cells), molecular biology (growth factors, genes), biomaterials, biomechanics, and translational science, a combined effort between scientists and clinicians with broad expertise may allow development of an improved cell therapy for cartilage repair. This position paper describes the current state of the art in the field to help define a procedure adapted to the clinical situation for upcoming translation in the patient.

Article download: Pages 12-16 (PDF file)
DOI: 10.22203/eCM.v027sa03