eCM (Eur Cell Mater / e Cells & Materials) Not-for-profit Open Access
Created by Scientists, for Scientists
 ISSN:1473-2262         NLM:100973416 (link)         DOI:10.22203/eCM

2014   Volume No 28 – pages 269-286

Title: Role and regulation of RUNX2 in osteogenesis

Author: M Bruderer, RG Richards, M Alini, MJ Stoddart

Address: AO Research Institute Davos, Clavadelerstrasse 8, CH-7270 Davos Platz, Switzerland

E-mail: martin.stoddart at aofoundation.org

Key Words: Stem cells, bone, osteogenesis, differentiation, transcription factor, RUNX2.

Publication date: October 23rd 2014

Abstract: Runt-related transcription factor 2 (RUNX2) is a transcription factor closely associated with the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its interactions within the osteoblast differentiation pathway are often overlooked. This review aims to summarise the knowledge of its regulation at the transcriptional, translational and post-translational level. In addition, the regulation of RUNX2 by factors commonly used during osteogenic studies will be discussed.

Article download: Pages 269-286 (PDF file)
DOI: 10.22203/eCM.v028a19