Volume No 20 - Supplement 2 - July
2010
eCM XI Cartilage & Disc: Repair and Regeneration
June 28-30, 2010, Davos, Switzerland
Abstracts of the meeting listed in order of presentation
Oral presentations
Development
Page 1: AG Cole
Diversity in the development and evolution of cartilages
Page 2: C Hartmann
The various functions of WNT-signalling in chondrogenesis
Page 3: J Ralphs, B Caterson, C Hughes, A Hayes
Chondroitin sulphate sulfation motifs in intervertebral disc development
Page 4: IM Khan, SL Evans, N Avery, CW Archer
Acceleration of post-natal articular cartilage maturation
Maintenance
Page 5: A Burleigh, O Boruc, J Saklatvala, T Vincent
The role of biomechanical factors in OA development
Page 6: AK Wann, J Mistry, A Michael-Titus, MM Knight
Eicosapenaenoic acid (EPA) and docasahexaenoic acid (DHA) reduce IL-1b mediated cartilage degradation
Page 7: I Prasadam, R Crawford, Y Xiao
Cell interactions of osteoarthritic subchondral bone osteoblasts and articular chondrocytes aggravate MMP-2 and MMP-9 production through the mediation of ERK1/2 and JNK phosphorylation
Page 8: MB Goldring, M Otero, DA Plumb, C Dragomir, K Hashimoto
Roles of inflammatory and anabolic cytokines in cartilage metabolism
Degeneration
Page 9: F Dell’Accio
Molecular mechanisms of cartilage regeneration
Page 10: C Neidlinger-Wilke, A Mietsch, UM Mauer, HJ Wilke, A Ignatius
Angiogenic factors, mechanical loads and oxygen supply: possible interactions in the regulation of degeneration associated disc angiogenesis?
Page 11: BM Minogue, SM Richardson, JA Hoyland
Identification of human nucleus pulposus (NP) and articular cartilage (AC) marker genes and their expression in the degenerate NP
Page 12: S Dudli, D Haschtmann, SJ Ferguson
Burst fracture of the vertebral endplates but not equienergetic impact load promotes in vitro disc degeneration
Scaffolds
Page 13: A Pandit
Hierarchical functionalization of scaffold – macro to nano
Page 14: MM Stevens
Modulation of cell behaviour through nanoscale architecture
Page 15: M Peroglio, D Mortisen, M Alini, D Eglin
Injectable thermoreversible hyaluronan-based hydrogels for interveterbral disc repair
Page 16: A Mujeeb, J Gough, A Saiani
Tailoring self-assembled octapeptide scaffolds for in-vitro cartilage repair
Page 17: D Vonwil, A Barbero, A Trüssel, O Haupt, I Martin
Substrate elasticity modulates TGF beta stimulated re-differentiation of expanded human articular chondrocytes
Mechano-Regulation
Page 18: JC Iatridis, AJ Michalek, A Barbir
Effects of shearing on intervertebral disc mechanics and biology
Page 19: AH Huang, MJ Farrell,
IE Erickson, M Kim, BM Baker, JA Burdick, RL Mauck
Mechanical stimulation enhances functional mesenchymal stem cell chondrogenesis in 3D culture
Page 20: AK Wann, SR McGlashan, CJ Haycraft, CA Poole, MM Knight
Primary cilia are essential for chondrocyte mechanotransduction
Page 21: EA Mitchell, AM White, SM Richardson, JA Hoyland
Development of an ex vivo disc model system to test novel therapies: Comparison of loaded isolated discs vs. whole motion segments
Clinical
Page 22: CW McIlwraith, DD Frisbie
Animal models for cartilage regeneration
Page 23: B von Rechenberg
Bone substitution in subchondral bone and its effect on hyaline cartilage – an experimental study in sheep
(No abstract)
Page 24: RM Porter, FJ Liu, E Ferreira, Z Shen, CH Evans
Non-destructive evaluation of human mesenchymal progenitor cell transcriptional activity within osteochondral defects
Page 25: J Hendriks, R Schotel, M van den Doel, J Riesle
Cellular synergy for one step cartilage repair
Page 26: JB Richardson
Runaway remodelling and its implications for treatment of osteoarthritis in the clinic
Page 27: C Schizas
Disc degeneration: current surgical techniques
Repair
Page 28: A Hollander
Stem cells and cartilage repair: turning science into medicine
Page 29: JA Hoyland, SM Richardson, B Minogue, AJ Freemont
Challenges for cell based regeneration of the degenerate intervertebral disc
Page 30: CÓ Flatharta, E Mooney, M Berdasco, G Shaw, M Esteller, FB Barry, JM Murphy
Downregulation of superfluous genes on commitment to chondrogenic differentiation of mesenchymal stem cells is associated with DNA hypermethylation
Page 31: M Cucchiarini, MD Menger, H Madry
Direct, rAAV-mediated overexpression of human IGF-I enhances articular cartilage repair in vivo
Posters
Page 32: C Acharya, A Adesida, P Zajac, S Schaeren, M Jakob, J Riesle, A Barbero,I Martin
Modalities of interaction between human primary chondrocytes and mesenchymal progenitor cells responsible for enhanced in vitro cartilage formation
Page 33: A Bertolo, N Aebli, M Baur, S Ferguson, J Stoyanov
Human mesenchymal stem cells differentiation into intervertebral disc-like tissue-comparison of different biodegradable matrixes
Page 34: SE Bulman, CM Coleman, M Murphy, F Barry
Pullulan enhances progenitor cell attachment on OA cartilage
Page 35: SCW Chan, SJ Ferguson, K Wuertz, B Gantenbein-Ritter
Effect of short term torsion to the intervertebral disc: an organ culture study
Page 36: PP Chong, AA Abbas, T Kamarul
Analysis of TGF-b3 and BFGF induced chondrogenic differentiation in human bone marrow-derived mesenchymal stem cells
Page 37: E Collin, S Grad, D Zeugolis, J Guicheux, P Weiss, M Alini, A Pandit
Injectable type II collagen-hyluronan hydrogel as reservoir system for nucleus pulposus regeneration
Page 38: S D’Arcy, CM Coleman, MJ Murphy, F Barry
hMSC TNAP expression is a marker of differentiation potential
Page 39: SE Darwiche, C Scaletta, MC Osterheld, W Raffoul, DP Pioletti, LA Applegate
Fetal epiphyseal chondrocyte master cell banking for osteochondral repair and regeneration
Page 40: N Franscini, E Bono, R Durner , K Wuertz, N Boos, U Graf-Hausner
Disc regeneration - automation for a new cell-based approach
Page 41: B Gantenbein-Ritter, C Seiler, SCW Chan, M Reyes, J Kühn, C Depeursinge
Quantifying cell shape changes of human mesenchymal stem cells undergoing differentiation
Page 42: R Gawri, J Moir, Ouellet, P Roughley, F Mwale, J Antoniou, T Steffen, L Haglund
Whole IVD organ culture systems to study the potential of biological repair
Page 43: K Gelse, J Gusinde, M Blanke, A Mauerer, B Swoboda, F Hennig
A dual chondrogenic and anti-angiogenic approach for cartilage repair
Page 44: F Gottsauner-Wolf, H Plenk Jr
Multiple neocartilage cushions supported a long-term subsided Smith-Peterson hip arthroplasty
Page 45: T Kamarul, T Tay, H Dastar, LX Tay, PP Chong, R Ali, AA Abbas
The use of chondrogenic differentiated mesenchymal stem cells in treating focal cartilage damage: preliminary study in animal model
Page 46: SR Kanthan, K Ganesan, M Azura, T Kamarul
The different preparations of human amniotic membrane (HAM) as a potential cell carrier for chondrocytes
Page 47: TJ Levingstone, G Dickson, FJ O’Brien, JP Gleeson
A multi-layer collagen-based scaffold for osteochondral defect repair
Page 48: A Marsano, P Bernegger, U Helmrich, S Schaeren, S Miot, A Barbero, I Martin, A Banfi
Generation of human nasal chondrocytes engineered to express soluble VEGF receptor-2 for cartilage tissue engineering
Page 49: A Matsiko, TJ Levingstone, FJ O’Brien, JP Gleeson
Addition of hyaluronic acid improves cellular infiltration and cartilage-specific extracellular matrix synthesis in a porous collagen scaffold
Page 50: M Mehr, A Bertolo, N Aebli, S Ferguson, J Stoyanov
The loss of differentiation potential of human mesenchymal stem cells can be predicted by use of a set of senescence markers
Page 51: A Mietsch, A Ignatius, UM Mauer, HJ Wilke, C Neidlinger-Wilke
Influence of oxygen concentration on nucleus pulposus cells in 3D pellet culture during long-term cultivation
Page 52: A Mietsch, C Neidlinger - Wilke, H Schrezenmeier, UM Mauer, B Friemert, HJ Wilke, A Ignatius
Platelet-rich plasma (PRP) and hydrostatic pressure influence cell differentiation in nucleus pulposus tissue engineering
Page 53: EA Mitchell, AM White, S Richardson, NW Hodson, MJ Sherratt, JA Hoyland
Using AFM to define the structure of collagen within a loaded intervertebral disc model system
Page 54: MW Naing, Y Liu, EA Rayment and DJ Williams
Multi-axial bioreactor for nucleus pulposus tissue engineering
Page 55: J O’Sullivan; CM Coleman; M Murphy, F Barry
Selection of chondroprogenitors from bone marrow by adhesion to chondroitin sulphate
Page 56: CPL Paul, HA Zuiderbaan, BZ Doulabi, AJ vd Veen, TH Smit, MN Helder, BJ van Royen, MG Mullender
Effects of short term loading on intervertebral disc cell viability in a loaded disc culture system
Page 57: H Plenk Jr, F Kanz, W Mayr, O Ploder
Unstable callus-distraction caused also growth plate-like cartilage islands in sheep mandibles
Page 58: H Pulkkinen, V Tiitu, P Valonen, TS Silvast, JS Jurvelin, J Töyräs, I Kiviranta,
MJ Lammi
Repair of osteochondral defects with recombinant human type II collagen gel and autologous chondrocytes in a rabbit model
Page 59: C Qu, H Lindeberg, MJ Lammi
Five percent oxygen tension is not beneficial for the neocartilage formation in scaffold-free primary chondrocyte cultures
Page 60: CM Rogers, TS Woolley, SC Cruwys, LDK Buttery, FRAJ Rose, KM Shakesheff
The effect of different culture environments on chondrocyte proliferation, differentiation and extracellular matrix production
Page 61: J Sague, S Honold, Y Loosli, J Vogt, R Luginbuehl
Modulating the materials properties of poly(HEMA-co-MMA) materials and their potential use as meniscal substitutes
Page 62: V Schmid, RJ Egli, R Luginbuehl, J Justiz
A Physiologic robot reactor system to simulate in vivo conditions
Page 63: MJ Stoddart, Z Li, D Eglin, M Alini
The role of mechanical load on the chondrogenesis of human bone derived mesenchymal stem cells in fibrin-polyurethane scaffolds
Page 64: J Walser, MD Caversaccio, SJ Ferguson
Rapid prototyping in cartilage tissue engineering
Page 65: PM Welz, K Ito, SJ Ferguson
Impact of exposing nucleus pulposus cells to direct current
Page 66: S Li, EJ Blain, VC Duance
The effects of physiological compression and strain on remodelling of the cytoskeleton and extracellular matrix in bovine intervertebral disc cells
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