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Open Access 23 Jul 2025Review
Exploring YAP1-TEAD interaction in multi-pathway regulation: potential repairing efficacy for bone defect
Y. Wu 1,§, H. Yang 2,§, X.L. Zhang 2, L. Liu 2, C. Xu 2, K.L. Wu 1, G.Y. Feng 1, W.J. Xu 1, F. Bai 2,3,*, X. Yang 1,*, C.P. Zhang 1,*
Affiliations
Article Info

1 Department of Oral Maxillofacial-Head Neck Oncology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Shanghai Research Institute of Stomatology, 200011 Shanghai, China

2 Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, 201210 Shanghai, China

3 School of Information Science and Technology, ShanghaiTech University; Shanghai Clinical Research and Trial Center, 201210 Shanghai, China

 

§ These authors equally contributed to this paper

Abstract

Bone defects present significant challenges, requiring timely restoration and regeneration in clinical practice. The restoration area of bone defects undergoes continuous bone formation and remodeling, regulated by a balance between bone generation and resorption. These processes of bone homeostasis are influenced by multi-pathway regulation. Yes-associated protein 1 (YAP1) and transcriptional enhanced associated domains (TEADs) are key components of the Hippo pathway. They serve as central regulators within these multi-pathway regulation networks, mediating both osteogenesis and osteoclastogenesis. YAP1 can be influenced by upstream Hippo pathway kinase modules, mechanical signals, and chemical cues, which regulate its interaction with TEAD through signaling pathways and post-translational modifications (PTMs), thereby modulating target protein transcription and various biological processes in bone homeostasis. In this review, we provide a current overview on YAP1-TEAD interactions as a crucial link in bone homeostasis, focusing on the upstream regulations, PTMs, and downstream target. Our aim is to elucidate the complex regulatory mechanisms of YAP1-TEAD and explore potential therapeutic strategies for bone defects.

Graphical Abstract

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Keywords

  • Bone defects
  • bone homeostasis
  • YAP1-TEAD interaction
  • Hippo pathway