2005 Volume No 9- pages 23-32
Title: Current strategies for articular cartilage repair
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Authors: S. N. Redman, S. F. Oldfield and C.W. Archer |
Address: CITER (Cardiff Institute of Tissue Engineering
and Repair), Cardiff School of Biosciences, Museum Avenue,
Cardiff, CF10 3US, Wales, UK |
E-mail: archer at cardiff.ac.uk |
Key Words: Cartilage Repair, Articular Cartilage, Mesenchymal Stem Cells, Cartilage Defects, Chondrocyte Plasticity.
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Publication date: April 14th 2005 |
Abstract: Defects of articular cartilage that do
not penetrate to the subchondral bone fail to heal spontaneously.
Defects that penetrate to the subchondral bone elicit an intrinsic
repair response that yields a fibrocartilaginous repair tissue
which is a poor substitute for hyaline articular cartilage.
Many arthroscopic repair strategies employed utilise this
intrinsic repair response to induce the formation of a repair
tissue within the defect. The goal, however, is to produce
a repair tissue that has the same functional and mechanical
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