eCM (Eur Cell Mater / e Cells & Materials) Not-for-Profit Open Access
Created by Scientists, for Scientists
 ISSN:1473-2262         NLM:100973416 (link)         DOI:10.22203/eCM

2008   Volume No 16 – pages 56-68

Title:The importance of loading frequency, rate and vibration for enhancing bone adaptation and implant osseointegration

Author: A Torcasio, GH van Lenthe, H Van Oosterwyck

Address:Division of Biomechanics and Engineering Design, K.U. Leuven, Leuven, Belgium

E-mail: hans.vanoosterwyck at

Key Words: Bone adaptation, loading frequency, strain rate, vibration, osseointegration, implant.

Publication date: November 27th 2008

Abstract: Mechanical loading is one of the key factors that influence bone mass and the osseointegration of bone-anchored implants. From a clinical point of view, mechanical stimulation may be used to enhance bone strength and implant osseointegration. Among the many loading parameters that influence the response to mechanical loading, the effects of loading frequency and rate have been investigated in many studies. In this paper the most relevant animal studies that have addressed the effect of loading frequency, rate, and vibration on either bone adaptation or implant osseointegration are systematically reviewed. Apparently contradictory results are discussed and interpreted within the context of mechanotransduction and mechanoregulation of bone. A combined experimental and computational approach is suggested to address some of the remaining research questions.

Article download: Pages 56-68 (PDF file)
DOI: 10.22203/eCM.v016a07