eCM (Eur Cell Mater / e Cells & Materials) Not-for-Profit Open Access
Created by Scientists, for Scientists
 ISSN:1473-2262         NLM:100973416 (link)         DOI:10.22203/eCM

2012   Volume No 24 – pages 46-59

Title: The importance of WNT pathways for bone metabolism and their regulation by implant topography

Author: C Galli, M Piemontese, S Lumetti, E Manfredi, GM Macaluso, G Passeri

Address: Sez. Odontostomatologia, University of Parma, Via Gramsci 14, 43100 Parma, Italy

E-mail: carlo.galli at

Key Words: Topography; WNT; titanium implants; osteoblasts; cytoskeleton.

Publication date: July 12th 2012

Abstract: Endosseous implants are important tools to replace missing teeth or damaged tissue segments. Their clinical success depends on their integration in bone and, thus, on the response of bone cells to material and surface characteristics. Recent evidence has shown that surface topography and chemistry affect WNT signalling, a pivotal pathway for the commitment of mesenchymal progenitors to the osteoblast lineage and for bone homeostasis. WNT signalling comprises several cascades that, acting through different effectors, modulate several aspects of cell behaviour.
It has been shown that cells growing on rough titanium surfaces display a different expression profile for WNT factors, and that surface features can alter the response of bone cells to WNT factors. Although the underlying mechanisms to this regulation are still poorly understood, the present review reports intriguing evidence that that cell cytoskeletal signalling is involved in activating WNT signalling in cells growing on rough implant surfaces.

Article download: Pages 46-59 (PDF file)
DOI: 10.22203/eCM.v024a04