2015 Volume No 29 pages 22-34
Title: Systemic mesenchymal stem cell administration enhances bone formation in fracture repair but not load-induced bone formation |
Author: AE Rapp, R Bindl, A Heilmann, A Erbacher, I Müller, RE Brenner, A Ignatius |
Address: Institute of Orthopaedic Research and Biomechanics, Helmholtzstr. 14, 89081 Ulm, Germany |
E-mail: anna.rapp at uni-ulm.de |
Key Words: mesenchymal stem cells, cell therapy, bone formation, fracture healing, mechanical loading, mouse model. |
Publication date: January 2nd 2015 |
Abstract: Mesenchymal stem cells (MSC) were shown to support bone regeneration, when they were locally transplanted into poorly healing fractures. The benefit of systemic MSC transplantation is currently less evident. There is consensus that systemically applied MSC are recruited to the site of injury, but it is debated whether they actually support bone formation. Furthermore, the question arises as to whether circulating MSC are recruited only in case of injury or whether they also participate in mechanically induced bone formation. |
Article download: Pages
22-34 (PDF file) |