2025 Volume No 52 – pages 80-97
Title: Designs, applications, and future perspectives of nanozymes in orthopedics and dentistry |
Authors: WD Gao, YQ Mu, L Xiao, Y Xiao |
Address: School of Medicine and Dentistry, Griffith University, Gold Coast Campus, 4222 Gold Coast, QLD, Australia; Institute for Biomedicine and Glycomics, Griffith University, Gold Coast Campus, 4222 Gold Coast, QLD, Australia; The Australia-China Centre for Tissue Engineering and Regenerative Medicine (ACCTERM), Queensland University of Technology (QUT), 4000 Brisbane, QLD, Australia |
E-mail: yin.xiao at griffith.edu.au |
Abstract: Nanozymes are nanomaterials that mimic enzyme activities by exhibiting notable enzyme-like kinetics and catalyze substrates under physiological conditions. Compared to natural enzymes, nanozymes offer advantages such as lower cost, higher stability, multi-enzymatic activity, and simpler preparation, making them promising alternatives in biomedical applications, particularly in bone and dental-related areas. This review presents a comprehensive overview of recent advances in nanozyme for orthopedic and dental application. The methodologies used to design and construct nanozymes are summarized, including composition regulation, size control, morphology engineering and surface modification. The applications of nanozymes in various stages of bone and dental tissue regeneration are then explored, with detailed discussions on their roles in in vitro diagnostics, anti-infection strategies, osteogenic microenvironment regulation, and combating bone tumors. The review highlights how nanozymes address key challenges in the field, such as reactive oxygen species management, immune response modulation, and targeted drug delivery. Furthermore, by addressing current challenges and outlining prospects, this review aims to advance the therapeutic potential of nanozymes in treating bone and dental diseases and bridge the gap towards their clinical translation. |
Keywords: Nanozymes, bone, microenvironment, immunomodulation, materials engineering, dentistry. |
Publication date: 28th August 2025 |
Copyright policy: © 2025 The Author(s). Published by Forum Multimedia Publishing, LLC. This article is distributed in accordance with Creative Commons Attribution Licence (http://creativecommons.org/licenses/by/4.0/). |
Article download: Pages 80-97 (PDF file) |
