2025 Volume No 52 – pages 114-131
Title: Novel post-translational modifications in bone remodeling: potential therapeutic strategies for osteoporosis |
Authors: ZJ Pan, HH Liu, LY Liu, QZ Wang, J Pan |
Address: Department of Oral and Maxillofacial Surgery, State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, 610041 Chengdu, Sichuan, China |
E-mail: qizhangwang at scu.edu.cn; jianpancn at scu.edu.cn |
Abstract: Osteoblast-induced bone formation and osteoclast-mediated bone resorption coordinate the balance of bone remodeling. However, the exact mechanisms underlying bone remodeling remain unknown. Several post-translational modifications (PTMs), including glycosylation, ubiquitination, sumoylation, lactylation, and palmitoylation, have been linked to bone remodeling. The core molecules involved in bone remodeling are widely modified by PTMs. An imbalance between bone resorption and formation is a prerequisite for osteoporosis. Therefore, targeting bone remodeling by modulating PTMs is a promising strategy for osteoporosis therapy. In this review we consider the roles of novel PTMs in bone remodeling, which may deepen our understanding of the mechanisms underlying bone remodeling and may also provide novel treatment targets for osteoporosis. |
Keywords: Bone remodeling, osteoporosis, post-translational modifications, glycosylation, ubiquitination, sumoylation, lactylation, palmitoylation. |
Publication date: 28th August 2025 |
Copyright policy: © 2025 The Author(s). Published by Forum Multimedia Publishing, LLC. This article is distributed in accordance with Creative Commons Attribution Licence (http://creativecommons.org/licenses/by/4.0/). |
Article download: Pages 114-131 (PDF file) |
